|
KMID : 0370220220660040210
|
|
Yakhak Hoeji
2022 Volume.66 No. 4 p.210 ~ p.215
|
|
|
Risk Factors Associated with Bisphosphonates Related Osteonecrosis of the Jaw: A National Insurance Senior Cohort Database Study
|
|
Kim Jun-Hyeob
Kim Tae-Hyeok
Lee Kyung-Eun
|
|
|
Abstract
|
|
|
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe side effect of bisphosphonate, which isusually prescribed as a treatment for diseases such as multiple myeloma, bone metastases, osteoporosis, and Paget disease.
To investigate the risk factors of BRONJ, we conducted a nested case-control study using the Korean National InsuranceHealth Service-senior cohort. Patients newly diagnosed with BRONJ were selected as the case group, while the controlgroup included patients who were never diagnosed with BRONJ. A risk-set sampling method was used to select thecontrol group using age, sex, the date of the first prescription of bisphosphonate, and follow-up duration. Of the 22,236subjects, 4,455 were included in the case group. Arthrosis, rheumatoid arthritis, neuropathies, myocardial infarction, renaldisease, cancer, liver disease, and tooth extraction were associated with a higher incidence of BRONJ than subjects withoutsuch conditions (aOR, 95% CI: 1.58 [1.47-1.71], 1.46 [1.30-1.63], 1.31 [1.20-1.42], 1.23 [1.01-1.49], 1.36 [1.10-1.68], 1.27[1.12-1.45], 1.63 [1.10-2.43], and 1.64 [1.53-1.76] respectively). In conclusion, of the factors examined, we confirmed thatliver disease and tooth extraction were related to an increased risk of BRONJ.
|
|
|
KEYWORD
|
|
|
Bisphosphonate, Bisphosphonate-associated Osteonecrosis of the Jaw, National Insurance Database
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|